What major disease pandemic occurred in the 14th century?

The Black Death, also known as the Bubonic Plague, is recognized as one of the most devastating pandemics in human history, occurring in the 14th century. It resulted in the deaths of an estimated 25 to 30 million people, which was about one-third of Europe's population at the time. The outbreak spread rapidly throughout Europe, Asia, and North Africa, largely due to the movement of traders and the conditions prevalent in urban areas. The Black Death was characterized by fever, painful swellings, and skin rashes, and it fundamentally changed societal structures across Europe, leading to significant cultural, economic, and social shifts.

The other pandemics mentioned occurred in different time periods or regions. The Spanish Flu took place in the early 20th century, primarily from 1918 to 1919. The Plague of Justinian preceded the Black Death, occurring in the 6th century, and while it also had a significant impact, it is not the correct answer for the 14th century context. The Smallpox Epidemic, while a severe affliction notably affecting indigenous populations during the colonization of the Americas, is not associated with the 14th century either. Thus, the Black Death stands as the defining major